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Iyada oo ku saleysan qalfoofka aza-BODIPY, NIR1001 waxay ku daraysaa kooxaha ku-deeqaha elektarooniga ah (tusaale, 4-N, N-diphenylaminophenyl) ee 2,6-meelood, samaynta qaab-dhismeedka D-π-D summaysan1. Naqshadani waxa ay yaraynaysaa farqiga HOMO-LUMO, iyada oo ka beddelaysa nuugista ugu sarreysa 1000 nm oo kor u qaadaysa wareejinta kharashka intramolecular (ICT). Gudaha THF, NIR1001 waxay soo bandhigaysaa nuugista laba-sawir ee ugu badnaan (TPA) ee 37 GM, horumar laba laab ah marka loo eego sooyaalka BODIPY ee soo jireenka ah. Cimrigeeda xiisaha-goboleed ee 1.2 ps waxay awood u siinaysaa kala-guuro hufan oo aan shucaac ahayn, taasoo ka dhigaysa mid ku habboon daawaynta sawir-qaadista (PDT).

Xisaabinta DFT waxay daaha ka qaadaysaa in habka wareejinta kharashka ee NIR1001 uu ka yimid π-elektrooniga kala-soocida qaybaha deeq bixiyayaasha iyo kuwa aqbala. Beddelka methoxy wuxuu sii kordhiyaa nuugista NIR ee daaqada daawaynta sawir-qaadista (650-900 nm), hagaajinta dareenka1. Marka la barbardhigo midabada AF ee Jaamacadda Fudan, NIR1001 waxay haysaa miisaan yar oo unugyo ah (<500 Da) oo leh 40% sawir-qaadis sare. Wax ka beddelka kaarboonku wuxuu hagaajiyaa milanka biyaha (cLogD=1.2), yaraynta xayeysiiska aan gaarka ahayn ee nidaamyada noolaha

3. Codsiyada Biomedical
Marka la eego bioimaging, hCG-conjugated probe hCG-NIR1001 waxay ku guulaysataa sawir-qaran sare ee follicle ugxan-sidaha iyo micro-metastases ka hooseeya 808 nm excitation. Iyadoo qoto dheer oo ah 3 cm gudaha NIR-II, waxay ka sarraysaa baaritaanka NIR-I saddex laab, iyadoo hoos u dhigaysa iftiinka asalka 60%. Qaabka dhaawaca kelyaha ee jiirka, NIR1001 waxay muujinaysaa 85% qaadashada gaarka ah ee kelyaha, ogaanshaha dhaawaca lix jeer ka dhakhso badan kontaroolada makromolecular.
PDT, NIR1001 waxay soo saartaa noocyada ogsijiinta falcelinta (ROS) ee 0.85 μmol/J ee hoos timaada 1064 nm shucaaca laser, si wax ku ool ah u kicinta apoptosis unugga buro. NIR1001 nanoparticles (NPs) ee Liposome-ku duuban waxay ku ururaan 7.2 jeer ka badan burooyinka marka loo eego dheeha bilaashka ah, taas oo yaraynaysa saamaynta bartilmaameedka ah.
4. Kormeerka Warshadaha iyo Deegaanka
Codsiyada warshadaha, NIR1001 waxaa lagu dhex daray Juhang Technology's SupNIR-1000 analyzer ee kala soocida miraha, qiimaynta tayada hilibka, iyo habaynta tubaakada. Ku shaqaynta qiyaasta 900-1700 nm, waxay si isku mar ah u cabbirtaa waxa ku jira sonkorta, qoyaanka, iyo haraaga sunta cayayaanka gudaha 30 ilbiriqsi iyada oo ± (50ppm + 5%) sax ah. Dareemayaasha CO2 ee baabuurta (ACDS-1001), NIR1001 waxay awood u siinaysaa la socodka wakhtiga dhabta ah ee T90≤25s wakhtiga jawaabta iyo cimriga 15-sano ah.
Si loo ogaado deegaanka, NIR1001-baarayaasha shaqaynaysa waxay ogaadaan biraha culus ee biyaha ku jira. pH 6.5-8.0, xoojinta fluorescence waxay si toos ah ula xiriirtaa xooga saarista Hg²⁺ (0.1-10 μM) oo leh xadka ogaanshaha ee 0.05 μM, ka sarreeya hababka midabaynta iyadoo la adeegsanayo laba amar oo waaweyn.
5. Hal-abuurka Farsamada iyo Ganacsiga
Agabka Qingdao TopwellShaqaalaysiisay isku-duubni joogto ah si uu u soo saaro NIR1001 oo ah 99.5% nadiif ah, oo leh 50 kg/awood dufcaddii. Isticmaalka reactors microchannel, wakhtiga uumiga ee Knoevenagel ayaa laga dhimay 12 saacadood ilaa 30 daqiiqo, iyada oo la jarayo isticmaalka tamarta 60%. Taxanaha ISO 13485-shahaadad ee NIR1001 ayaa xukuma suuqa cilmiga noolaha.